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Treatment of mild to moderately severe infections caused by penicillin sensitive staphylococci, pneumococci, gonococci and haemolytic streptococci infections. Therapy should be guided by bacteriological studies, including sensitivity tests, and by clinical response.

For prophylactic use in recurrent streptococcal infections including the prevention of recurrence following rheumatic fever and/or Sydenham’s chorea and to prevent bacterial endocarditis in patients with rheumatic fever and/or congenital heart disease who are about to undergo dental or upper respiratory surgery or instrumentation.

Note: Oral penicillin should not be used as adjunctive prophylaxis for genitourinary instrumentation or surgery, lower intestinal tract surgery, sigmoidoscopy or childbirth.

Treatment of mild to moderately severe infections caused by penicillin sensitive staphylococci, pneumococci, gonococci and haemolytic streptococci infections. Therapy should be guided by bacteriological studies, including sensitivity tests, and by clinical response.

For prophylactic use in recurrent streptococcal infections including the prevention of recurrence following rheumatic fever and/or Sydenham’s chorea and to prevent bacterial endocarditis in patients with rheumatic fever and/or congenital heart disease who are about to undergo dental or upper respiratory surgery or instrumentation.

Note: Oral penicillin should not be used as adjunctive prophylaxis for genitourinary instrumentation or surgery, lower intestinal tract surgery, sigmoidoscopy or childbirth.

Abelcet is indicated for the treatment of invasive fungal disease caused by organisms susceptible to amphotericin B

Pain

Tetracycline hydrochloride is indicated in infections caused by the following micro organisms: Rickettsiae (Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox, tick fever). Mycoplasma pneumoniae (PPLO, Eaton agent). Agents of psittacosis. Agents of lymphogranuloma venereum and granuloma inguinale. The spirochaetal agent of relapsing fever (Borrelia recurrentis).

The following Gram-negative micro organism: Haemophilus ducreyi (chancroid), Pasteurella pestis and Pasteurella tularensis, Bartonella bacilliformis, Bacteroides species. Vibrio comma an Vibrio foetus. Brucella species (in conjection with streptomycin).

Tetracycline may be used for treatment of infections caused by the following Gram-negative micro organisms only when bacteriological testing indicates appropriate susceptibility to the drug: Escherichia coli, Enterobacter aerogenes (formerly Aerobacter aerogenes), Shigella species, Mima species and Herellea species, Haemophilus influenzae (respiratory infections), Klebsiella species (respiratory and urinary infections).

Tetracycline may be used for the treatment of infections caused by the following Gram- positive micro organisms when bacteriological testing indicates appropriate susceptibility to the drug: Streptococcus species: Up to 44% of strains of Streptococcus pyogenes and 74% of Streptococcus faecalis have been found to be resistant to tetracyclines. Therefore, tetracycline should not be used for streptococcal disease unless the organism has been demonstrated to be sensitive For upper respiratory infection due to group A ?-haemolytic streptococci (Streptococcus pyogenes), penicillin is the usual drug of choice, including prophylaxis of rheumatic fever. Streptococcus pneumoniae, Staphylococcus aureus in skin and soft tissue infections.

Tetracyclines are not the drug of choice in the treatment of any type of staphylococcal infection.

When penicillin is contraindicated, tetracyclines are alternative drugs in the treatment of infections due to: Treponema pallidum and Treponema pertenue (syphilis and yaws), Listeria monocytogenes, Clostridium species, Bacillus anthracis, Fusobacterium fusiforme (Vincent’s infection), Actinomyces species.

In acute intestinal amoebiasis, the tetracyclines may be a useful adjunct to amoebicides. In severe acne, the tetracyclines may be useful adjunctive therapy.

Tetracycline is indicated in the treatment of trachoma, although the infectious agent is not always eliminated, as judged by immunofluorescence.

Inclusion conjunctivitis may be treated with oral tetracyclines or with a combination of oral and topical agents.

Aclor is indicated for the treatment of the following types of infections caused by or likely to be caused by susceptible organisms:

• Lower respiratory infections, including pneumonia, bronchitis and exacerbations of chronic bronchitis.
• Upper respiratory infections, including pharyngitis, tonsillitis and otitis media. Skin and skin structure infections.
• Urinary tract infections, including pyelonephritis and cystitis.

Treatment of type 2 diabetes mellitus inadequately controlled by diet and exercise:

• as monotherapy;
• as dual therapy to improve glycaemic control
• - in combination with metformin or sulfonylurea
• - in combination with insulin;
• as triple therapy to improve glycaemic control, in combination with metformin and sulfonylurea.

Treatment of hypertension. It may be used alone or in combination with thiazide diuretics. Sufficient data have not been provided to support the use of quinapril in renovascular hypertension.

Congestive heart failure. Adjunctive treatment of mild to moderate congestive heart failure when given concomitantly with a diuretic and/or cardiac glycoside.

Relief of unproductive, dry and intractable coughs associated with colds and flu.

Actiq is indicated for the management of breakthrough cancer pain in patients with malignancies who are already receiving and are tolerant to opioid therapy for their underlying persistent cancer pain.